NUVECTIS PHARMA, INC.

is a clinical stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology.

NXP900 is an oral small molecule inhibitor of the SRC Family of Kinases (SFK), including SRC and YES1. NXP900 has a unique mechanism of action (Type 1.5 inhibitor) which results in inhibition of both the catalytic and scaffolding functions of the SRC kinase, thereby providing a complete shutdown of the signaling pathway. NXP900 completed a dose escalation study in patients with advanced solid tumors and a drug-drug interaction study in healthy volunteers, supporting the phase 1b program to evaluate the safety and efficacy of NXP900 as a single agent and in combination with other anti-cancer agents.

NXP800 is an oral small molecule that exerts its biologic activity through activation of the kinase GCN2. Following the final data update from a Phase 1b clinical trial that evaluated NXP800 for the treatment of platinum resistant, ARID1a-mutated ovarian cancer that demonstrated that NXP800 was biologically active, evaluation of the feasibility of other development opportunities in which NXP800 can potentially demonstrate its anti-cancer activity more profoundly are being explored. NXP800 is also being evaluated for the treatment of cholangiocarcinoma in an investigator-sponsored clinical trial led by Mayo clinic.

NUVECTIS PHARMA, INC.

is a clinical stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology.

NXP900 is an oral small molecule inhibitor of the SRC Family of Kinases (SFK), including SRC and YES1. NXP900 has a unique mechanism of action (Type 1.5 inhibitor) which results in inhibition of both the catalytic and scaffolding functions of the SRC kinase, thereby providing a complete shutdown of the signaling pathway. NXP900 completed a dose escalation study in patients with advanced solid tumors and a drug-drug interaction study in healthy volunteers, supporting the phase 1b program to evaluate the safety and efficacy of NXP900 as a single agent and in combination with other anti-cancer agents.

NXP800 is an oral small molecule that exerts its biologic activity through activation of the kinase GCN2. Following the final data update from a Phase 1b clinical trial that evaluated NXP800 for the treatment of platinum resistant, ARID1a-mutated ovarian cancer that demonstrated that NXP800 was biologically active, evaluation of the feasibility of other development opportunities in which NXP800 can potentially demonstrate its anti-cancer activity more profoundly are being explored. NXP800 is also being evaluated for the treatment of cholangiocarcinoma in an investigator-sponsored clinical trial led by Mayo clinic.

Management Team

Ron Bentsur

Chairman, Chief Executive Officer and President

Enrique Poradosu, PhD

Executive Vice President, Chief Scientific and Business Officer

Shay Shemesh

Shay Shemesh

Executive Vice President, Chief Development and Operations Officer

Board of Directors

Ron Bentsur

Chairman, Chief Executive Officer and President

Ken Hoberman

Director

Matthew L. Kaplan

Director

James F. Oliviero, III

Director

Juan Sanchez, MD

Director